BDBM536239 (2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthalene-1,5'-[1,2,4]oxadiazol]-3'-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 131.3::US11242344, Example 131.4

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)CC1C1=NOC2(CCCc3ccccc23)N1)c1cc(C)no1

InChI Key InChIKey=DYVCCEQFPYNQOG-PJXQYFAUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 536239   

LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.96E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  2.00E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.99E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  2.30E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent