BDBM536244 (5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-prolyl) pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl) phenyl)-1,5-dihydro-4H-imidazol-4-one (2 Single Stereoisomers)::US11242344, Example 112.1::US11242344, Example 112.2

SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1S(C)(=O)=O

InChI Key InChIKey=JMHDAGHLLTXOHA-CAQGRGCHSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 536244   

LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataIC50:  2.33E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataIC50:  6.64E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataKd:  1.21E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent