BDBM536244 (5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-prolyl) pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl) phenyl)-1,5-dihydro-4H-imidazol-4-one (2 Single Stereoisomers)::US11242344, Example 112.1::US11242344, Example 112.2
SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1S(C)(=O)=O
InChI Key InChIKey=JMHDAGHLLTXOHA-CAQGRGCHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 536244
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 2.33E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataKd: 1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Affinity DataIC50: 6.64E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataKd: 1.21E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair