BDBM536251 (2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 133.3::US11242344, Example 133.4

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(N1)(c1ccc(Br)cc1)C(F)(F)F)c1cc(C)no1

InChI Key InChIKey=QYHDCFRWZLANQW-VVTKKKPISA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536251   

LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataIC50:  3.44E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataKd:  3.63E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataIC50:  5.23E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataIC50:  5.49E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataKd:  1.74E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataIC50:  2.26E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent