BDBM536264 1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl) butan-1-one (2 Single Stereoisomers)::US11242344, Example 115.1::US11242344, Example 115.2

SMILES CCN1N=C(NC1(C)C)[C@@H]1C[C@@H](O)CN1C(=O)C(C(C)C)c1cc(C)no1

InChI Key InChIKey=JEBUBKJHZDBEKS-CNYCQXTOSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536264   

LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataIC50:  4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataIC50:  2.57E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataIC50:  4.07E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataKd:  4.03E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataIC50:  1.00E+5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent