BDBM536961 US11896597, Compound 78
SMILES Cc1ccc(cc1)-c1cc(ccc1F)-c1nn(c(CC2CC2)c1Cc1ccc(cc1)S(N)(=O)=O)-c1nc(cs1)C(O)=O
InChI Key InChIKey=FKERUWBBIXEJRA-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 536961
TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 24.6nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 16.4nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Affinity DataIC50: 69.4nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 19.7nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 0.300nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair