BDBM536968 US11896597, Compound 84

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)nn(-c3nc(cs3)C(O)=O)c2-c2cccc(c2)-c2ccccc2)cc1F

InChI Key InChIKey=YMQUYPIOONYKGV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 536968   

TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536968(US11896597, Compound 84)
Affinity DataIC50:  259nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536968(US11896597, Compound 84)
Affinity DataIC50:  116nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetegfr wt(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536968(US11896597, Compound 84)
Affinity DataIC50:  604nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536968(US11896597, Compound 84)
Affinity DataIC50:  1.56E+3nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536968(US11896597, Compound 84)
Affinity DataIC50:  0.400nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent