BDBM537979 US11248003, Example TRE-069
SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)C1CCNCC1
InChI Key InChIKey=FJMLHLTVDMXQCW-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 537979
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 2.10E+3nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210](Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 20nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 15nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 6nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 16nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair