BDBM542547 (1S,3′R,6′R,7′S,8′E,15′R)-6-CHLORO-15′-HYDROXY-7′-METHOXY-12′-METHYL-13′-OXO-N-(2-PYRIDINYLSULFONYL)-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12]DIAZATETRACYCLO[14.7.2.03,6.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXAMIDE::US11274105, Example 34

SMILES CO[C@H]1\C=C\CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)c2ccccn2)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=NAGFGCQLXYWKKD-JCBDOFPHSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 542547   

LigandPNGBDBM542547((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0920nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542547((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  0.200nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542547((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  5.14nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent