BDBM542588 (3R,6R,7S,11S,17R,24S)-6′-CHLORO-17-HYDROXY-14-METHYL-N-(METHYLSULFONYL)-15-OXO-3′,4′-DIHYDRO-2′H-SPIRO[8,22-DIOXA-1,14-DIAZAPENTACYCLO[16.7.2.17,11.03,6.021,26]OCTACOSA-18,20,26-TRIENE-24,1′-NAPHTHALENE]-17-CARBOXAMIDE::US11274105, Example 78
SMILES CN1CC[C@H]2CCO[C@@H](C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(C)(=O)=O
InChI Key InChIKey=WUGRXIVVHRGVFO-DXSCVPPESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 542588
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataKi: 0.0810nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.25nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 7.33nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair