BDBM542589 (3R,6R,7S,11S,17R,24S)-6′-CHLORO-N-(CYCLOPROPYLSULFONYL)-17-HYDROXY-14-METHYL-15-OXO-3′,4′-DIHYDRO-2′H-SPIRO[8,22-DIOXA-1,14-DIAZAPENTACYCLO [16.7.2.17,11.03,6.021,26]OCTACOSA-18,20,26-TRIENE-24,1′-NAPHTHALENE]-17-CARBOXAMIDE::US11274105, Example 79

SMILES CN1CC[C@H]2CCO[C@@H](C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(=O)(=O)C1CC1

InChI Key InChIKey=YHGZZFRUNBTLET-PWPUSZHTSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 542589   

LigandPNGBDBM542589((3R,6R,7S,11S,17R,24S)-6′-CHLORO-N-(CYCLOPRO...)
Affinity DataKi:  0.0920nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542589((3R,6R,7S,11S,17R,24S)-6′-CHLORO-N-(CYCLOPRO...)
Affinity DataIC50:  0.300nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542589((3R,6R,7S,11S,17R,24S)-6′-CHLORO-N-(CYCLOPRO...)
Affinity DataIC50:  8.75nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent