BDBM542679 (1 S,3′R,6′R,7′S, 8′E,15′R)-6-CHLORO-N-(CYCLOPROPYLSULFONYL)-15′-HYDROXY-12′-METHYL-7′-(2-(4-MORPHOLINYL)ETHOXY)-13′-OXO-3,4-DIHYDRO-2H-SPIRO [NAPHTHALENE-1,22′-[20] OXA[1,12]DIAZATETRACYCLO [14.7.2.03,6.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXAMIDE::US11274105, Example 178
SMILES CN1CC\C=C\[C@H](OCCN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(=O)(=O)C1CC1
InChI Key InChIKey=QEDUEKQIUSVGAC-QNIOLGHGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 542679
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataKi: 0.0350nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.180nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.940nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair