BDBM542712 (1S,3′R,6′R,7′S,8′E,15′S)-6-CHLORO-7′,15′-DIHYDROXY-12′-METHYL-13′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12,25]TRIAZATETRACYCLO[14.7.2.0˜3,6˜.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXYLIC ACID::US11274105, Example 209a::US11274105, Example 209b

SMILES CN1CC\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(nc23)[C@](O)(CC1=O)C(O)=O

InChI Key InChIKey=OHZKSJICZAECKO-TUIZYCDUSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 542712   

LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0960nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.572nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  5.34nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  3.69nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  71nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542712((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  0.650nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent