BindingDB BDBM5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid

BDBM5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908

SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

Data 3 KI 157 IC50 780 Kd 2 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 5445

Epidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 1.48E+4nMAssay Description:Inhibiton of EGFR L858R/T790M mutant (unknown origin) expressed in human NCI-H1975 cells assessed as reduction in EGFR induced cell viability after 9...More data for this Ligand-Target Pair

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MMDB
PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 2.69E+3nMAssay Description:Inhibiton of EGFR (unknown origin) expressed in human A431 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo a...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 24nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 0.200nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as sub...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 0.0600nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preinc...More data for this Ligand-Target Pair

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3D Structure (crystal)

Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)

IC50: 2.80nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair

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Filter my 942 hits

Targets 397▿
- Epidermal growth factor receptor 108
- Receptor tyrosine-protein kinase erbB-2 47
- Tyrosine-protein kinase ABL1 23
- Mast/stem cell growth factor receptor Kit 15
- Receptor-type tyrosine-protein kinase FLT3 12
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 12
- Receptor tyrosine-protein kinase erbB-4 9
- Proto-oncogene tyrosine-protein kinase receptor Ret 6
- Bile salt export pump 5
- Ephrin type-A receptor 6 4
- Insulin-like growth factor 1 receptor 4
- Ribosomal protein S6 kinase alpha-6 4
- Ribosomal protein S6 kinase alpha-4 4
- Ribosomal protein S6 kinase alpha-5 4
- Ribosomal protein S6 kinase alpha-2 4
- Ribosomal protein S6 kinase alpha-1 4
- Hepatocyte growth factor receptor 4
- Platelet-derived growth factor receptor beta 4
- Mitogen-activated protein kinase 14 4
- Serine/threonine-protein kinase B-raf 4
- Vascular endothelial growth factor receptor 2 4
- Fibroblast growth factor receptor 3 4
- Serine/threonine-protein kinase PLK1 3
- Death-associated protein kinase 3 3
- Tyrosine-protein kinase JAK1 3
- Receptor-interacting serine/threonine-protein kinase 2 3
- Platelet-derived growth factor receptor alpha 3
- Potassium voltage-gated channel subfamily H member 2 3
- Cyclin-dependent kinase 2 3
- Serine/threonine-protein kinase 10 3
- STE20-like serine/threonine-protein kinase 3
- Non-receptor tyrosine-protein kinase TYK2 3
- Myosin light chain kinase, smooth muscle 3
- Insulin receptor 3
- Glycogen synthase kinase-3 alpha 3
- Tyrosine-protein kinase Tec 2
- BMP-2-inducible protein kinase 2
- Cyclin-dependent kinase 11B 2
- Cyclin-dependent kinase 11A 2
- LIM domain kinase 1 2
- LIM domain kinase 2 2
- ALK tyrosine kinase receptor 2
- NUAK family SNF1-like kinase 2 2
- Glycogen synthase kinase-3 beta 2
- Calcium/calmodulin-dependent protein kinase type 1 2
- NUAK family SNF1-like kinase 1 2
- Calcium/calmodulin-dependent protein kinase type II subunit beta 2
- AP2-associated protein kinase 1 2
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2
- Serine/threonine-protein kinase PAK 1 2
- Protein kinase C theta type 2
- Serine/threonine-protein kinase PAK 2 2
- Serine/threonine-protein kinase PAK 3 2
- Dual specificity mitogen-activated protein kinase kinase 2 2
- Serine/threonine-protein kinase PAK 4 2
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 2
- Serine/threonine-protein kinase tousled-like 2 2
- Dual specificity mitogen-activated protein kinase kinase 3 2
- Serine/threonine-protein kinase PAK 5 2
- Serine/threonine-protein kinase PAK 6 2
- Serine/threonine-protein kinase tousled-like 1 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Dual specificity mitogen-activated protein kinase kinase 1 2
- Dual specificity mitogen-activated protein kinase kinase 6 2
- Dual specificity mitogen-activated protein kinase kinase 4 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Tyrosine-protein kinase ZAP-70 2
- Casein kinase I isoform gamma-3 2
- Casein kinase I isoform gamma-2 2
- Casein kinase I isoform epsilon 2
- Casein kinase I isoform gamma-1 2
- Ephrin type-A receptor 1 2
- Ephrin type-A receptor 3 2
- Ephrin type-A receptor 2 2
- Ephrin type-A receptor 5 2
- Tyrosine-protein kinase BTK 2
- Ephrin type-A receptor 4 2
- Tyrosine-protein kinase receptor UFO 2
- Activin receptor type-1 2
- Myosin light chain kinase 2, skeletal/cardiac muscle 2
- Voltage-dependent L-type calcium channel subunit alpha-1C 2
- Tyrosine-protein kinase Srms 2
- Wee1-like protein kinase 2
- Ankyrin repeat and protein kinase domain-containing protein 1 2
- Tyrosine-protein kinase Lyn 2
- Focal adhesion kinase 1 2
- Tyrosine-protein kinase TXK 2
- Ephrin type-A receptor 8 2
- Death-associated protein kinase 2 2
- Death-associated protein kinase 1 2
- Serine/threonine-protein kinase D2 2
- Serine/threonine-protein kinase D3 2
- TGF-beta receptor type-2 2
- Serine/threonine-protein kinase D1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Cyclin-dependent kinase 9 2
- Cyclin-dependent kinase 8 2
- Serine/threonine-protein kinase pim-3 2
- Cyclin-dependent kinase 7 2
- Serine/threonine-protein kinase pim-1 2
- Cyclin-dependent kinase 5 2
- Serine/threonine-protein kinase pim-2 2
- Cyclin-dependent kinase 4 2
- Cyclin-dependent kinase 3 2
- Serine/threonine-protein kinase 36 2
- Testis-specific serine/threonine-protein kinase 1 2
- Cyclin-dependent kinase 16 2
- Protein kinase C epsilon type 2
- Cyclin-dependent kinase 17 2
- Bone morphogenetic protein receptor type-2 2
- Cyclin-dependent kinase 19 2
- Protein-tyrosine kinase 6 2
- Casein kinase II subunit alpha 2
- Cyclin-dependent kinase 14 2
- Leukocyte tyrosine kinase receptor 2
- Cytoplasmic tyrosine-protein kinase BMX 2
- Tyrosine-protein kinase ABL2 2
- Atypical kinase COQ8B, mitochondrial 2
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 2
- cGMP-dependent protein kinase 2 2
- cGMP-dependent protein kinase 1 2
- Serine/threonine-protein kinase SIK2 2
- Tyrosine-protein kinase Fes/Fps 2
- Serine/threonine-protein kinase SIK1 2
- 3-phosphoinositide-dependent protein kinase 1 2
- Mitogen-activated protein kinase 1 2
- Serine/threonine-protein kinase 3 2
- Discoidin domain-containing receptor 2 2
- Mitogen-activated protein kinase 3 2
- Mitogen-activated protein kinase 4 2
- Serine/threonine-protein kinase 4 2
- Mitogen-activated protein kinase 9 2
- SRSF protein kinase 2 2
- Mitogen-activated protein kinase 6 2
- Mitogen-activated protein kinase 7 2
- Mitogen-activated protein kinase 8 2
- Calcium/calmodulin-dependent protein kinase type IV 2
- Tyrosine-protein kinase SYK 2
- Serine/threonine-protein kinase RIO1 2
- Serine/threonine-protein kinase LATS1 2
- Serine/threonine-protein kinase RIO3 2
- Serine/threonine-protein kinase 32B 2
- Serine/threonine-protein kinase 32C 2
- Tyrosine-protein kinase HCK 2
- Vascular endothelial growth factor receptor 3 2
- Vascular endothelial growth factor receptor 1 2
- Insulin receptor-related protein 2
- Serine/threonine-protein kinase PLK3 2
- Serine/threonine-protein kinase PLK4 2
- Tyrosine-protein kinase receptor TYRO3 2
- Serine/threonine-protein kinase BRSK1 2
- Serine/threonine-protein kinase LATS2 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- Citron Rho-interacting kinase 2
- Serine/threonine-protein kinase BRSK2 2
- Serine/threonine-protein kinase Chk1 2
- cAMP-dependent protein kinase catalytic subunit PRKX 2
- SRSF protein kinase 1 2
- Tyrosine-protein kinase Yes 2
- Serine/threonine-protein kinase MRCK beta 2
- Serine/threonine-protein kinase MRCK gamma 2
- Casein kinase II subunit alpha' 2
- Serine/threonine-protein kinase STK11 2
- Cyclin-G-associated kinase 2
- Tyrosine-protein kinase FRK 2
- Serine/threonine-protein kinase Nek9 2
- Serine/threonine-protein kinase Nek7 2
- Serine/threonine-protein kinase Nek6 2
- Serine/threonine-protein kinase Nek5 2
- Serine/threonine-protein kinase Nek2 2
- Serine/threonine-protein kinase Nek1 2
- Serine/threonine-protein kinase receptor R3 2
- MAP/microtubule affinity-regulating kinase 3 2
- MAP kinase-interacting serine/threonine-protein kinase 2 2
- MAP kinase-interacting serine/threonine-protein kinase 1 2
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 2
- MAP/microtubule affinity-regulating kinase 4 2
- Serine/threonine-protein kinase 38-like 2
- Dual specificity protein kinase TTK 2
- Myosin-IIIb 2
- Myosin-IIIa 2
- Tyrosine-protein kinase ITK/TSK 2
- Myotonin-protein kinase 2
- Protein kinase C eta type 2
- Bone morphogenetic protein receptor type-1A 2
- Receptor-interacting serine/threonine-protein kinase 1 2
- Tyrosine-protein kinase Blk 2
- Serine/threonine-protein kinase 16 2
- Non-receptor tyrosine-protein kinase TNK1 2
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 2
- Serine/threonine-protein kinase NLK 2
- Casein kinase I isoform delta 2
- Cyclin-dependent kinase 18 [3-474] 2
- RAF proto-oncogene serine/threonine-protein kinase 2
- Serine/threonine-protein kinase 26 2
- Serine/threonine-protein kinase 24 2
- Dual specificity testis-specific protein kinase 1 2
- Serine/threonine-protein kinase 25 2
- Ephrin type-B receptor 3 2
- Serine/threonine-protein kinase 33 2
- Ephrin type-B receptor 4 2
- Ephrin type-B receptor 1 2
- Ephrin type-B receptor 2 2
- Activated CDC42 kinase 1 2
- MAP kinase-activated protein kinase 2 2
- Epithelial discoidin domain-containing receptor 1 2
- MAP kinase-activated protein kinase 5 2
- Muscle, skeletal receptor tyrosine-protein kinase 2
- Tyrosine-protein kinase Fer 2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 2
- Tyrosine-protein kinase receptor Tie-1 2
- Calcium/calmodulin-dependent protein kinase type II subunit delta 2
- Proto-oncogene tyrosine-protein kinase ROS 2
- Calcium/calmodulin-dependent protein kinase kinase 1 2
- Serine/threonine-protein kinase DCLK1 2
- Calcium/calmodulin-dependent protein kinase kinase 2 2
- Serine/threonine-protein kinase DCLK2 2
- Serine/threonine-protein kinase DCLK3 2
- Angiopoietin-1 receptor 2
- Serine/threonine-protein kinase TNNI3K 2
- Interferon-induced, double-stranded RNA-activated protein kinase 2
- Mitogen-activated protein kinase kinase kinase kinase 3 2
- Mitogen-activated protein kinase kinase kinase kinase 1 2
- Serine/threonine-protein kinase MRCK alpha 2
- Casein kinase I isoform alpha-like 2
- Mitogen-activated protein kinase kinase kinase kinase 4 2
- Mitogen-activated protein kinase kinase kinase kinase 5 2
- Mitogen-activated protein kinase 15 2
- Broad substrate specificity ATP-binding cassette transporter ABCG2 2
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 2
- Activin receptor type-1B 2
- Myosin light chain kinase family member 4 2
- Mitogen-activated protein kinase kinase kinase 9 2
- RAC-gamma serine/threonine-protein kinase 2
- Mitogen-activated protein kinase kinase kinase 5 2
- Interleukin-1 receptor-associated kinase 3 2
- Mitogen-activated protein kinase kinase kinase 4 2
- RAC-alpha serine/threonine-protein kinase 2
- Proto-oncogene tyrosine-protein kinase Src 2
- Activin receptor type-2B 2
- Activin receptor type-2A 2
- BDNF/NT-3 growth factors receptor 2
- Serine/threonine-protein kinase 17A 2
- Tyrosine-protein kinase Lck 2
- Serine/threonine-protein kinase 17B 2
- Dual specificity protein kinase CLK1 2
- Protein kinase C delta type 2
- NT-3 growth factor receptor 2
- Dual specificity protein kinase CLK4 2
- Dual specificity protein kinase CLK3 2
- Dual specificity protein kinase CLK2 2
- Protein-tyrosine kinase 2-beta 2
- High affinity nerve growth factor receptor 2
- Tyrosine-protein kinase Mer 2
- Serine/threonine-protein kinase N2 2
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 2
- cAMP-dependent protein kinase catalytic subunit beta 2
- Serine/threonine-protein kinase N1 2
- Ribosomal protein S6 kinase alpha-3 2
- Calcium/calmodulin-dependent protein kinase type 1D 2
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2
- Calcium/calmodulin-dependent protein kinase type 1G 2
- Fibroblast growth factor receptor 4 2
- Tyrosine-protein kinase Fgr 2
- Aurora kinase B 2
- Mitogen-activated protein kinase kinase kinase 20 2
- Fibroblast growth factor receptor 1 2
- Aurora kinase A 2
- Fibroblast growth factor receptor 2 2
- Atypical kinase COQ8A, mitochondrial 2
- Aurora kinase C 2
- Mitogen-activated protein kinase 12 2
- Mitogen-activated protein kinase 11 2
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 2
- RAC-beta serine/threonine-protein kinase 2
- Mitogen-activated protein kinase 10 2
- Tyrosine-protein kinase Fyn 2
- Tyrosine-protein kinase CSK 2
- Macrophage colony-stimulating factor 1 receptor 2
- eIF-2-alpha kinase GCN2 2
- Maternal embryonic leucine zipper kinase 2
- Serine/threonine-protein kinase MARK1 2
- Serine/threonine-protein kinase MARK2 2
- TRAF2 and NCK-interacting protein kinase 2
- Mitogen-activated protein kinase kinase kinase 10 2
- Mitogen-activated protein kinase kinase kinase 11 2
- Peripheral plasma membrane protein CASK 1
- Tubulin alpha-1A chain 1
- Rhodopsin kinase GRK1 1
- Uncharacterized serine/threonine-protein kinase SBK3 1
- Receptor tyrosine-protein kinase erbB-3 1
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Protein kinase C iota type 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Macrophage-stimulating protein receptor 1
- Cyclin-dependent kinase-like 3 1
- Cyclin-dependent kinase-like 2 1
- Serine/threonine-protein kinase SIK3 [59-1321] 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- Cyclin-dependent kinase-like 5 1
- Potassium voltage-gated channel subfamily E/KQT member 1 1
- Epidermal growth factor receptor [1-999,L858R] 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Serine/threonine-protein kinase Sgk3 1
- Myosin light chain kinase 3 1
- Serine/threonine-protein kinase Nek11 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Bone morphogenetic protein receptor type-1B 1
- SNF-related serine/threonine-protein kinase 1
- ATP-dependent translocase ABCB1 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Receptor-interacting serine/threonine-protein kinase 4 1
- Ribosomal protein S6 kinase beta-1 1
- Serine/threonine-protein kinase OSR1 1
- Serine/threonine-protein kinase MAK 1
- Histone deacetylase 8 1
- Serine/threonine-protein kinase/endoribonuclease IRE1 1
- Histone deacetylase 6 1
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 1
- Histone deacetylase 3 1
- Histone deacetylase 1 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Serine/threonine-protein kinase SBK1 1
- Ephrin type-B receptor 6 1
- Rhodopsin kinase GRK7 1
- STE20/SPS1-related proline-alanine-rich protein kinase 1
- Phosphatidylinositol 4-kinase beta 1
- Calcium-dependent protein kinase 1 1
- Dual serine/threonine and tyrosine protein kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Serine/threonine-protein kinase TAO1 1
- Serine/threonine-protein kinase PknB 1
- Serine/threonine-protein kinase 38 1
- Serine/threonine-protein kinase TAO3 1
- Serine/threonine-protein kinase 35 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Sodium channel protein type 5 subunit alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Cyclin-dependent kinase 2 homolog 1
- Cyclin-dependent kinase 13 1
- Cyclin-dependent kinase 15 1
- Interleukin-1 receptor-associated kinase 4 1
- Serine/threonine-protein kinase VRK2 1
- Mitogen-activated protein kinase kinase kinase 6 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Mitogen-activated protein kinase kinase kinase 3 1
- Serine/threonine-protein kinase ICK 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Microtubule-associated serine/threonine-protein kinase 1 1
- ATP-binding cassette sub-family C member 2 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Serine/threonine-protein kinase ULK1 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- Mitogen-activated protein kinase kinase kinase 19 1
- Mitogen-activated protein kinase kinase kinase 15 1
- SRSF protein kinase 3 1
- G protein-coupled receptor kinase 4 1
- Serine/threonine-protein kinase TBK1 1
- Hormonally up-regulated neu tumor-associated kinase 1
- Serine/threonine-protein kinase RIO2 1
- Serine/threonine-protein kinase 32A 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Cytochrome P450 3A5 1
- Cytochrome P450 3A4 1
- Serine/threonine-protein kinase PLK2 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase NIM1 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Wee1-like protein kinase 2 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Serine/threonine-protein kinase Chk2 1
- Epidermal growth factor receptor [G719C] 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Mitogen-activated protein kinase kinase kinase 13 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- ...
Publications 50▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Nat Biotechnol 26: 127-32 (2008) 318
- J Med Chem 53: 8546-55 (2010) 12
- Bioorg Med Chem Lett 30: (2020) 7
- J Pharmacol Toxicol Methods 70: 246-54 (2014) 7
- J Med Chem 63: 11725-11755 (2020) 6
- Eur J Med Chem 87: 631-42 (2014) 5
- Bioorg Med Chem Lett 19: 6437-40 (2009) 4
- Toxicol Sci 136: 216-41 (2013) 4
- Nat Biotechnol 23: 329-36 (2005) 4
- Bioorg Med Chem Lett 22: 456-60 (2011) 4
- Eur J Med Chem 198: (2020) 3
- Bioorg Med Chem Lett 20: 6067-71 (2010) 3
- Bioorg Med Chem 20: 125-36 (2011) 3
- J Biol Chem 286: 18756-65 (2011) 3
- Eur J Med Chem 233: (2022) 3
- J Med Chem 61: 11372-11383 (2018) 3
- Proc Natl Acad Sci U S A 105: 2773-8 (2008) 3
- Bioorg Med Chem Lett 20: 2452-5 (2010) 3
- Bioorg Med Chem Lett 30: (2020) 3
- Eur J Med Chem 156: 918-932 (2018) 3
- US Patent US10507209 (2019) 3
- Bioorg Med Chem 25: 27-37 (2017) 3
- J Med Chem 55: 2846-57 (2012) 3
- US Patent US9730934 (2017) 3
- Eur J Med Chem 94: 175-94 (2015) 2
- Bioorg Med Chem 20: 877-85 (2012) 2
- J Med Chem 62: 4772-4778 (2019) 2
- US Patent US10822334 (2020) 2
- Eur J Med Chem 211: (2021) 2
- Bioorg Med Chem Lett 16: 2419-22 (2006) 2
- Bioorg Med Chem Lett 25: 5147-54 (2015) 2
- Bioorg Med Chem Lett 26: 677-83 (2016) 2
- Eur J Med Chem 214: (2021) 2
- Eur J Med Chem 69: 833-41 (2013) 2
- Eur J Med Chem 170: 55-72 (2019) 2
- J Med Chem 52: 6880-8 (2009) 2
- J Med Chem 53: 1413-37 (2010) 2
- J Med Chem 53: 2000-9 (2010) 2
- Eur J Med Chem 120: 26-36 (2016) 2
- Eur J Med Chem 142: 131-151 (2017) 2
- Bioorg Med Chem 25: 6523-6535 (2017) 2
- Bioorg Med Chem Lett 21: 1601-6 (2011) 2
- Bioorg Med Chem Lett 16: 4686-91 (2006) 2
- Bioorg Med Chem Lett 14: 111-4 (2004) 2
- Bioorg Med Chem Lett 19: 817-20 (2009) 2
- J Med Chem 55: 4896-933 (2012) 1
- J Med Chem 63: 11397-11419 (2020) 1
- PubChem Bioassay (2008) 1
- J Med Chem 62: 10005-10025 (2019) 1
- ...
Institutions 38▿
- Ambit Biosciences 765
- University Of Regensburg 15
- Glaxosmithkline 8
- University Of Oxford 7
- Sabila Biosciences 7
- Abbott Laboratories 6
- Tu Dortmund University 6
- Shionogi 6
- Xuanzhu Pharma 6
- Southeast University 5
- Hanmi Research Center 5
- China Pharmaceutical University 5
- Shanghai Hengrui Pharmaceuticals 4
- Amgen 4
- Al-Azhar University 3
- Takeda Pharmaceutical 3
- Beijing University Of Chemical Technology 3
- Tsinghua University 3
- Jiangsu Aosaikang Pharmaceutical 3
- National Research Centre 3
- Gsk 3
- Schering-Plough 2
- Arromax Pharmatech 2
- University Of North Carolina At Chapel Hill 2
- Palack£ 2
- Korea University Of Science And Technology (Ust) 2
- Qilu Pharmaceutical 2
- Curis 2
- East China University Of Science And Technology 2
- Panjab University 2
- TBA 2
- Ain Shams University 2
- Nanjing University 2
- Norwegian University Of Science And Technology 2
- Zhengzhou University 2
- Boston University 1
- Pfizer 1
- Norman Drug Discovery Training And Consulting 1
- ...
Affinity: 0.060 to 1.0E+8 nM▿
- Ki 3
- IC50 157
- Kd 780
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1