BDBM5457 6-alkoxy-4-anilinoquinazoline 8c::N-(3-chloro-4-fluorophenyl)-6-{4-[(2-methanesulfonylethyl)amino]butoxy}quinazolin-4-amine

SMILES CS(=O)(=O)CCNCCCCOc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key InChIKey=SPEQBPSZWOMRLO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5457   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5457(6-alkoxy-4-anilinoquinazoline 8c | N-(3-chloro-4-f...)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5457(6-alkoxy-4-anilinoquinazoline 8c | N-(3-chloro-4-f...)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed