BDBM547807 WO2022090481, Example I-022::WO2022090481, Example I-064

SMILES COCCN1CCN(CC1)c1nc2c(nc(cc2n1C)-n1ncc2c(C)nc(cc12)-c1cnccc1OC)N1C[C@H]2C[C@@H]1CO2

InChI Key InChIKey=NBILLXVMFPDPPM-FGZHOGPDSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 547807   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  1nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  27nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor/Interleukin-3(Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  2.94E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  2.71E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  3.70nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  14nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  7.40nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  19nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  12nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  34nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  7.80nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed