BDBM550338 4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-6-chloro-1-(4,6-diisopropylpyrimidin-5-yl)-7-(2-fluoro-6-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-one::US11306087, Ex. # 11::US11306087, Ex. # 8

SMILES CC(C)c1ncnc(C(C)C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=YNFRTYXMDXBLOY-MOPGFXCFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 550338   

TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550338(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  136nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550338(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  30nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent