BDBM550351 4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-6-chloro-1-(4,6-diisopropylpyrimidin-5-yl)pyrido[2,3-d]pyrimidin-2(1H)-one::US11306087, Ex. # 21

SMILES CC(C)c1ncnc(C(C)C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@H](C)N([C@H](C)C1)C(=O)C=C)-c1c(N)cccc1F

InChI Key InChIKey=YQXFJCQQRXOHDV-KDURUIRLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550351   

TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550351(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-7-(2...)
Affinity DataIC50:  92nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent