BDBM550717 US11311527, Cpd ID I-11::US11376246, Cpd ID I-11::US11576906, Compound I-11

SMILES COc1cc2[nH]c(=O)c(CNc3cccn(C)c3=O)cc2cc1Cl

InChI Key InChIKey=DAJPKGHXCGODGX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 550717   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50:  550nMAssay Description:Please see paper.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Please see paper.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound 1 was not initially reported as having the greatest biochemical potency compared to reports for certain other small molecule inhibitors of m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:The cellular potency of Compound 1 in suppressing intracellular 2-HG levels was determined in cell lines expressing five different mutated IDH-1 prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50:  550nMAssay Description:Compound 1 was not initially reported as having the greatest biochemical potency compared to reports for certain other small molecule inhibitors of m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM550717(US11311527, Cpd ID I-11 | US11376246, Cpd ID I-11 ...)
Affinity DataIC50:  550nMAssay Description:The cellular potency of Compound 1 in suppressing intracellular 2-HG levels was determined in cell lines expressing five different mutated IDH-1 prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent