BDBM550787 7-Phenyl-8-(quinolin-6-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 3::US11312705, Example 3

SMILES Nc1nc(-c2ccccc2)c(-c2ccc3ncccc3c2)c2nncn12

InChI Key InChIKey=WKPXEMPFLXSVPV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 550787   

TargetAdenosine receptor A2a(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550787(7-Phenyl-8-(quinolin-6-yl)-[1,2,4]triazolo[4,3-c]p...)
Affinity DataIC50:  0.0700nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550787(7-Phenyl-8-(quinolin-6-yl)-[1,2,4]triazolo[4,3-c]p...)
Affinity DataIC50:  2nMAssay Description:CHO-K1/A3R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 10 μg/ml puromycin. The cells were digested with the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550787(7-Phenyl-8-(quinolin-6-yl)-[1,2,4]triazolo[4,3-c]p...)
Affinity DataIC50:  18nMAssay Description:CHO-K1/A1R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 1 mg/ml G418. The cells were digested with the cell separatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550787(7-Phenyl-8-(quinolin-6-yl)-[1,2,4]triazolo[4,3-c]p...)
Affinity DataIC50:  0.0700nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent