BDBM552685 (2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-oxopropan-2-yl)-l-((S)-2-(4-((2-acetamidoethoxy)methyl)-lH-l,2,3-triazol-I-yl)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide ( Compound 14)::WO2022103411, Example S14

SMILES CC(=O)NCCOCc1cn(nn1)[C@H](C(=O)N1C[C@H](O)CC1C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O)C(C)(C)C

InChI Key InChIKey=ZZWDGXXZRUGUSA-HWMCGDIZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552685   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552685((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  2.07E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552685((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  80nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed