BDBM552725 (2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l-yl)-3,3-dimethylbutanoyl)-4-hydroxy-N-((R)-2,2,2-trifluoro-l-(4-(4-methylthiaz,ol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide ( Compound 46)::WO2022103411, Compound 46::WO2022103411, Example S40

SMILES Cc1ncsc1-c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](n1cc(nn1)C1CC1)C(C)(C)C)C(F)(F)F

InChI Key InChIKey=RUFFBTSQMOUGGE-NZRJUOQRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552725   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552725((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...)
Affinity DataIC50:  80nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed