BDBM552728 (2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l-yl)-3,3-dimethylbutanoyl)-N-((2'-fluoro-[l,l'-biphenyl]-4-yl)methyl)-4-hydroxypyrrolidine-2-carboxamide (Compound 49)::WO2022103411, Compound 49::WO2022103411, Example S43

SMILES CC(C)(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1ccccc1F)n1cc(nn1)C1CC1

InChI Key InChIKey=OJJGAZIJCYHMEE-QGUKFAFCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552728   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552728((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...)
Affinity DataIC50:  30nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed