BDBM553804 US11325884, Compound 1a-non-racemic::US11325884, Compound 1a-racemic

SMILES NCCCCC(NC(=O)C1CCCC1)C(=O)COc1c(F)ccc(F)c1F

InChI Key InChIKey=OLIMBXKACVCIMM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 553804   

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  2.95E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50: <0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  170nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent