BDBM556331 5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(1-methylpiperidin-4-yloxy)pyridin-2-yl)pyrimidin-2-amine (Compound 65)::US11351170, Example 10

SMILES CN1CCC(CC1)Oc1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1

InChI Key InChIKey=KHTQGWKOTJZKCD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556331   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556331(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.260nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556331(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  136nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556331(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  64.1nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556331(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  2.46nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent