BDBM556337 2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yloxy)piperidin-1-yl)ethanol (Compound 87)::US11351170, Example 14

SMILES CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(OC3CCN(CCO)CC3)cn2)ncc1F

InChI Key InChIKey=WQGCPJJNZKLUAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556337   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556337(2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dih...)
Affinity DataIC50:  0.25nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556337(2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dih...)
Affinity DataIC50:  213nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556337(2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dih...)
Affinity DataIC50:  70.3nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556337(2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dih...)
Affinity DataIC50:  2.72nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent