BDBM556478 2-(3-(4-(((2-(4′-fluoro-[1,1′-biphenyl]-4-yl)cyclopropyl)amino)methyl)piperidin-1-yl)propyl)-N-hydroxythiazole-4-carboxamide TFA Salt::US11352322, Compound 111

SMILES ONC(=O)c1csc(CCCN2CCC(CNC3CC3c3ccc(cc3)-c3ccc(F)cc3)CC2)n1

InChI Key InChIKey=BFGHWQXCTUHMMX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556478   

TargetHistone deacetylase 6(Homo sapiens (Human))
Jubilant Epicore

US Patent
LigandPNGBDBM556478(2-(3-(4-(((2-(4′-fluoro-[1,1′-biphenyl...)
Affinity DataIC50:  2.98E+3nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Jubilant Epicore

US Patent
LigandPNGBDBM556478(2-(3-(4-(((2-(4′-fluoro-[1,1′-biphenyl...)
Affinity DataIC50:  22nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent