BDBM557721 (1S,3'R,6'R,7'R,11'S,12'R)-7'-((2r,3aR,6aS)- 5-acetyltetrahydro-3aH-[1,3]dioxolo[4,5- c]pyrrol-2-yl)-6-chloro-11',12'-dimethyl-3,4- dihydro-2H,15'H-spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]diazatetracyclo [14.7.2.0~3,6~.0~19,24~]pentacosa[16,18,24] trien]-15'-one 13',13'-dioxide AND::US11364248, Example 16::US11364248, Example 37

SMILES C[C@H]1CCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)[C@@H]1O[C@@H]2CN(C[C@@H]2O1)C(C)=O

InChI Key InChIKey=PQGVOPRFNQYBCR-RZIDHPANSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557721   

LigandPNGBDBM557721((1S,3'R,6'R,7'R,11'S,12'R)-7'-((2r,3aR,6aS)- 5-ace...)
Affinity DataIC50:  0.0980nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM557721((1S,3'R,6'R,7'R,11'S,12'R)-7'-((2r,3aR,6aS)- 5-ace...)
Affinity DataIC50:  0.194nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent