BDBM557737 (1S,3'R,6'R,7'R,11'S,12'R)-6-chloro-7'- ((2S,4S)-4-((dimethylamino)methyl)-1,3- dioxolan-2-yl)-11',12'-dimethyl-3,4-dihydro- 2H,15'H-spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]diazatetracyclo [14.7.2.0~3,6~.0~19,24~]pentacosa[16,18,24] trien]-15'-one 13',13'-dioxide or::US11364248, Example 33::US11364248, Example 34

SMILES C[C@H]1CCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)[C@@H]1OC[C@H](CN(C)C)O1

InChI Key InChIKey=WBUFPBNBXQNQBC-LWXAEIROSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557737   

LigandPNGBDBM557737((1S,3'R,6'R,7'R,11'S,12'R)-6-chloro-7'- ((2S,4S)-4...)
Affinity DataIC50:  11.1nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM557737((1S,3'R,6'R,7'R,11'S,12'R)-6-chloro-7'- ((2S,4S)-4...)
Affinity DataIC50:  0.612nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent