BDBM557778 (1S,3'R,6'S,7'S,12'R)-6-chloro-7'-(cis-5- (dimethylamino)-1,3-dioxan-2-yl)-12'-ethyl- 3,4-dihydro-2H,15'H-spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]diazatetracyclo [14.7.2.0~3,6~.0~19,24~]pentacosa[16,18,24] trien]-15'-one 13',13'-dioxide OR::US11364248, Example 73::US11364248, Example 74

SMILES CC[C@@H]1CCCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS1(=O)=O)[C@@H]1OC[C@@H](CO1)N(C)C

InChI Key InChIKey=NTJFVGFDJPOJBU-NZSMNFKTSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557778   

LigandPNGBDBM557778((1S,3'R,6'S,7'S,12'R)-6-chloro-7'-(cis-5- (dimethy...)
Affinity DataIC50:  0.196nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM557778((1S,3'R,6'S,7'S,12'R)-6-chloro-7'-(cis-5- (dimethy...)
Affinity DataIC50:  0.657nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent