BDBM557802 (1S,3′R,6′R,7′S,8′E,11′5,12′R)-6-CHLORO-7′-(CIS-5-(DIMETHYLAMINO)-1,3-DIOXAN-2-YL)-11′,12′-DIMETHYL-3,4-DIHYDRO-2H,15′H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[13]THIA[1,14]DIAZATETRACYCLO[14.7.2.0˜3,6˜.0˜19,24˜]PENTACOSA[8,16,18,24]TETRAEN]-15′-ONE 13′,13′-DIOXIDE::US11364248, Example 97

SMILES C[C@H]1C\C=C\[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)[C@@H]1OC[C@@H](CO1)N(C)C

InChI Key InChIKey=ZDAIJCZMUJQCQW-KBVCYCPCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 557802   

LigandPNGBDBM557802((1S,3′R,6′R,7′S,8′E,11R...)
Affinity DataIC50:  0.308nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent