BDBM557824 1-[4-[6-[5-[[6-(1-methoxy-1-methyl-ethyl)pyrazin-2-yl]amino]-1-methyl-pyrazol-4-yl]-3-pyridyl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride::US11365185, Example 6B

SMILES COC(C)(C)c1cncc(Nc2c(cnn2C)-c2ccc(cn2)-c2ccc(cc2)C2(CC2)C(O)=O)n1

InChI Key InChIKey=XAKNTOZVGAZPRK-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 557824   

TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557824(1-[4-[6-[5-[[6-(1-methoxy-1-methyl-ethyl)pyrazin-2...)
Affinity DataKi:  115nMAssay Description:The ability of a compound to inhibit binding of a ligand (1-(4′-(4-(((benzyloxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1′-biphenyl]-4-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557824(1-[4-[6-[5-[[6-(1-methoxy-1-methyl-ethyl)pyrazin-2...)
Affinity DataIC50:  122nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557824(1-[4-[6-[5-[[6-(1-methoxy-1-methyl-ethyl)pyrazin-2...)
Affinity DataIC50:  5.27E+3nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent