BDBM557831 1-[4-[6-[5-[[6-(1-fluoro-1-methyl-ethyl)pyrazin-2-yl]amino]-1-methyl-pyrazol-4-yl]-3-pyridyl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride::US11365185, Example 13B

SMILES Cn1ncc(c1Nc1cncc(n1)C(C)(C)F)-c1ccc(cn1)-c1ccc(cc1)C1(CC1)C(O)=O

InChI Key InChIKey=SWATWOUWJLKSFA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 557831   

TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557831(1-[4-[6-[5-[[6-(1-fluoro-1-methyl-ethyl)pyrazin-2-...)
Affinity DataKi:  28nMAssay Description:The ability of a compound to inhibit binding of a ligand (1-(4′-(4-(((benzyloxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1′-biphenyl]-4-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557831(1-[4-[6-[5-[[6-(1-fluoro-1-methyl-ethyl)pyrazin-2-...)
Affinity DataIC50:  44nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557831(1-[4-[6-[5-[[6-(1-fluoro-1-methyl-ethyl)pyrazin-2-...)
Affinity DataIC50:  804nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent