BDBM557833 1-[3-(cyanomethyl)-4-[6-[5-[(6-isopropylpyrazin-2-yl)amino]-1-methyl-pyrazol-4-yl]-3-pyridyl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride::US11365185, Example 15B

SMILES CC(C)c1cncc(Nc2c(cnn2C)-c2ccc(cn2)-c2ccc(cc2CC#N)C2(CC2)C(O)=O)n1

InChI Key InChIKey=XGGYBDMIXLZPFU-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 557833   

TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557833(1-[3-(cyanomethyl)-4-[6-[5-[(6-isopropylpyrazin-2-...)
Affinity DataKi:  94.8nMAssay Description:The ability of a compound to inhibit binding of a ligand (1-(4′-(4-(((benzyloxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1′-biphenyl]-4-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557833(1-[3-(cyanomethyl)-4-[6-[5-[(6-isopropylpyrazin-2-...)
Affinity DataIC50:  42.9nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557833(1-[3-(cyanomethyl)-4-[6-[5-[(6-isopropylpyrazin-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent