BDBM557844 1-[4-[4-[5-[(6-isopropylpyrazin-2-yl)amino]-1-methyl-pyrazol-4-yl]phenyl]phenyl]cyclopropanecarboxylic Acid::US11365185, Example 26B

SMILES CC(C)c1cncc(Nc2c(cnn2C)-c2ccc(cc2)-c2ccc(cc2)C2(CC2)C(O)=O)n1

InChI Key InChIKey=IZIGBCMMMQBBNV-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 557844   

TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557844(1-[4-[4-[5-[(6-isopropylpyrazin-2-yl)amino]-1-meth...)
Affinity DataKi:  18.8nMAssay Description:The ability of a compound to inhibit binding of a ligand (1-(4′-(4-(((benzyloxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1′-biphenyl]-4-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557844(1-[4-[4-[5-[(6-isopropylpyrazin-2-yl)amino]-1-meth...)
Affinity DataIC50:  23.6nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM557844(1-[4-[4-[5-[(6-isopropylpyrazin-2-yl)amino]-1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent