BDBM558465 2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]cyclopropane-1-carboxylic Acid::US11365192, Example 70-3::US11365192, Example 71-45::US11365192, Example 71-46

SMILES OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 558465   

TargetCytochrome P450 4F2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  280nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 4A11(Homo sapiens)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  28nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 4A11(Homo sapiens)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  19nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 4A11(Homo sapiens)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  15nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 4F2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  240nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 4F2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM558465(2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...)
Affinity DataIC50:  210nMAssay Description:In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent