BDBM562339 (−)-2,3,14-Trimethyl-7-[3-(1-naphthyloxy)propyl]-11,12,14,15-tetrahydro-2H,10H-pyrazolo[3′,4′:4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid 13,13-dioxide-N-ethylethanamine Salt (Enantiomer 2)::US11401278, Example 12

SMILES CN1Cc2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c(C(O)=O)n(CCCS1(=O)=O)c23

InChI Key InChIKey=JYNTXMBHJAXDSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562339   

LigandPNGBDBM562339((−)-2,3,14-Trimethyl-7-[3-(1-naphthyloxy)pro...)
Affinity DataIC50:  110nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562339((−)-2,3,14-Trimethyl-7-[3-(1-naphthyloxy)pro...)
Affinity DataIC50:  1.50E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562339((−)-2,3,14-Trimethyl-7-[3-(1-naphthyloxy)pro...)
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent