BDBM562354 (rac)-1-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)propyl)-13-fluoro-8,11,12-trimethyl-5,6,9,11-tetrahydro-4H,8H-pyrazolo[3′,4′:4,5][1]thia[2,8]diazacycloundecino[6,7,8-hi]indole-2-carboxylic acid 7,7-dioxide::US11401278, Example 27

SMILES CN1Cc2nn(C)c(C)c2-c2c(F)ccc3c(CCCOc4cccc5CCCc45)c(C(O)=O)n(CCCS1(=O)=O)c23

InChI Key InChIKey=TUUSACXFNUFQKW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562354   

LigandPNGBDBM562354((rac)-1-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)propyl)...)
Affinity DataIC50:  2.10nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562354((rac)-1-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)propyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562354((rac)-1-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)propyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent