BDBM562367 (rac)-4-chloro-14-cyclopropyl-2,3-dimethyl-7-[3-(1-naphthyloxy)propyl]-11,12,14,15-tetrahydro-2H,10H-pyrazolo[3′,4′:4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid 13,13-dioxide::US11401278, Example 40

SMILES Cc1[nH]nc2CN(C3CC3)S(=O)(=O)CCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34

InChI Key InChIKey=HABXBCFVEWAMPQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562367   

LigandPNGBDBM562367((rac)-4-chloro-14-cyclopropyl-2,3-dimethyl-7-[3-(1...)
Affinity DataIC50:  2.10nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562367((rac)-4-chloro-14-cyclopropyl-2,3-dimethyl-7-[3-(1...)
Affinity DataIC50:  1.90E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM562367((rac)-4-chloro-14-cyclopropyl-2,3-dimethyl-7-[3-(1...)
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent