BDBM562789 4-(((2S,5R,6S)-4-((R)-1-(1H-Tetrazol-5-yl)butyl)-5,6-bis(4-chlorophenyl)-3-oxomorpholin-2-yl)methyl)-2-fluorobenzonitrile::US11407721, Example 35

SMILES CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(C#N)c(F)c2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1nnn[nH]1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562789   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM562789(4-(((2S,5R,6S)-4-((R)-1-(1H-Tetrazol-5-yl)butyl)-5...)
Affinity DataIC50:  403nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM562789(4-(((2S,5R,6S)-4-((R)-1-(1H-Tetrazol-5-yl)butyl)-5...)
Affinity DataIC50:  473nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent