BDBM571417 (2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxymethyl)phenyl] prop-2-yn-1-ylidene}-3,3- dimethylpiperidin-1- yl]methanone::US11440922, Example 46

SMILES Cc1cc(C(=O)N2CC\C(=C/C#Cc3cccc(CO)c3)C(C)(C)C2)c(C)o1

InChI Key InChIKey=BCKNSIHAWJUFNY-UFFVCSGVSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571417   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571417((2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxyme...)
Affinity DataKi:  323nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571417((2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxyme...)
Affinity DataEC50:  37.4nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent