BDBM571429 US11440922, Example 166::{(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-3,3- dimethylpiperidin-1- yl}(4,6- dimethoxypyrimidin-2- yl)methanone

SMILES COc1cc(OC)nc(n1)C(=O)N1CC\C(=C/C#Cc2cccc(Cl)c2)C(C)(C)C1

InChI Key InChIKey=XJJDNCBKLYFUTJ-RQZCQDPDSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571429   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571429(US11440922, Example 166 | {(4E)-4-[3-(3- chlorophe...)
Affinity DataKi:  2.24nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571429(US11440922, Example 166 | {(4E)-4-[3-(3- chlorophe...)
Affinity DataEC50:  51.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent