BDBM572257 8-[3-(5-fluoro-2-pyridyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]- 1,8-diazaspiro[5.5]undecane::US11447505, Example E170

SMILES Oc1ccc(nc1)-c1c[nH]c2nccc(N3CCCC4(CCCCN4)C3)c12

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572257   

TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572257(8-[3-(5-fluoro-2-pyridyl)-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataKi:  0.100nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572257(8-[3-(5-fluoro-2-pyridyl)-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataKi:  0.170nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572257(8-[3-(5-fluoro-2-pyridyl)-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataKi:  165nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572257(8-[3-(5-fluoro-2-pyridyl)-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataKi:  564nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent