BDBM572310 4-[(2R)-2-methylpyrrolidin- 1-yl]-1H-pyrrolo[2,3- b]pyridine-3-carbonitrile::US11447505, Example E110

SMILES C[C@@H]1CCCN1c1ccnc2[nH]cc(C#N)c12

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572310   

TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572310(4-[(2R)-2-methylpyrrolidin- 1-yl]-1H-pyrrolo[2,3- ...)
Affinity DataKi:  1.44nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572310(4-[(2R)-2-methylpyrrolidin- 1-yl]-1H-pyrrolo[2,3- ...)
Affinity DataKi:  2.44nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572310(4-[(2R)-2-methylpyrrolidin- 1-yl]-1H-pyrrolo[2,3- ...)
Affinity DataKi:  2.77nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572310(4-[(2R)-2-methylpyrrolidin- 1-yl]-1H-pyrrolo[2,3- ...)
Affinity DataKi:  4.60nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent