BDBM572317 4-(azepan-4-yloxy)-3- pyrimidin-5-yl-1H- pyrrolo[2,3-b]pyridine::US11447505, Example E216

SMILES C1CNCCC(C1)Oc1ccnc2[nH]cc(-c3cncnc3)c12

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572317   

TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572317(4-(azepan-4-yloxy)-3- pyrimidin-5-yl-1H- pyrrolo[2...)
Affinity DataKi:  1.13nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572317(4-(azepan-4-yloxy)-3- pyrimidin-5-yl-1H- pyrrolo[2...)
Affinity DataKi:  1.78nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572317(4-(azepan-4-yloxy)-3- pyrimidin-5-yl-1H- pyrrolo[2...)
Affinity DataKi:  55.8nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572317(4-(azepan-4-yloxy)-3- pyrimidin-5-yl-1H- pyrrolo[2...)
Affinity DataKi:  66.8nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent