BDBM585342 5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperidin-1- yl)pyrimidine-2,4-diamine::US11530198, Example 94

SMILES CCc1ncc(cn1)-c1cccc(c1)C1CCN(CC1)c1cnc(N)nc1N

InChI Key InChIKey=ULOUWSHZZVXAHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 585342   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585342(5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperidin-1...)
Affinity DataIC50:  0.891nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585342(5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperidin-1...)
Affinity DataIC50:  324nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent