BDBM594271 US11584747, Example 65::US11584747, Example 66

SMILES CC[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1cccc(n1)C(F)(F)F)c1nc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=KMHRZLOQGQZITG-CLYKLVJSSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 594271   

TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594271(US11584747, Example 65 | US11584747, Example 66)
Affinity DataIC50:  1.19E+3nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594271(US11584747, Example 65 | US11584747, Example 66)
Affinity DataIC50:  100nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594271(US11584747, Example 65 | US11584747, Example 66)
Affinity DataIC50:  110nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha [9-727](Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594271(US11584747, Example 65 | US11584747, Example 66)
Affinity DataIC50:  2nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594271(US11584747, Example 65 | US11584747, Example 66)
Affinity DataIC50:  230nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent