BDBM601934 4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 2

SMILES NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=IAPISFUJUUDVNW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 601934   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  0.400nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  0.5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  41nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  98nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  200nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  3.70nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  2.80nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  1.40nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  1.30nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601934(4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,...)
Affinity DataIC50:  4.5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent