BDBM601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23

SMILES NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=FKAJEPVSQITQLJ-MRXNPFEDSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 601941   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  19nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  45nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  682nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  20nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  6nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  12nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601941((S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'...)
Affinity DataIC50:  11nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent