BDBM605528 (1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- indazol-5-yl)-2-pyridyl]-3- (methanesulfonamido)cyclohexanecarboxamide::US11673893, Example 6

SMILES CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NS(C)(=O)=O)ncc1Cl

InChI Key InChIKey=XUOBMFPQIZTUAZ-GOEBONIOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605528   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605528((1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  338nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605528((1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  0.794nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605528((1S,3R)-N-[5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  36.9nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent