BDBM605534 (1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-methyl-2H- indazol-5-yl)pyridin-2-yl)-3-(3-methoxyureido)cyclohexane- 1-carboxamide::US11673893, Example 12

SMILES CONC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nn(C)c(C(C)C)c2c1

InChI Key InChIKey=VHBMYACYAMWWOX-GOEBONIOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605534   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605534((1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  102nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605534((1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  0.489nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605534((1S,3R)-N-(5-chloro-4-(7-fluoro-3-isopropyl-2-meth...)
Affinity DataIC50:  19.7nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent